| Year | Awards | Awarding Unit |
|---|---|---|
| 2023-2025 | Postdoctoral Fellowship | American Heart Association |
| 2021 | Postdoctoral Research Abroad Program Scholarship | Ministry of Science and Technology, Taiwan |
| 2020 | The Award of Academic Research Thesis in Doctor | National Taiwan University |
| 2019 | Award of Veterinary Elite, Doctor of Philosophy Scholarship Award | Dr. Robert Chong-Dao Lee Foundation |
| 2019 | Postdoctoral Fellow | Higher Education Sprout Project |
| 2019 | The Award of Academic Research Thesis in Doctor | National Taiwan University |
| 2018 | Mr. G. X. Liu Outstanding Research Award | National Taiwan University |
| 2018 | Graduate Students Study Abroad Program Scholarship | Ministry of Science and Technology |
| 2017 | The Award of Academic Research Thesis in Doctor | National Taiwan University |
| 2017 | 2016 – 2017 Novus International Graduate Scholarship | Novus International, Inc. |
| 2016 | Mr. Y. S. Yu scholarship | the Agricultural Association of Taiwan |
| 2016 | Honorable Mention, National biotechnology innovative entrepreneurship competition | Ministry of Education |
| 2016 | Animal science research scholarship | National Taiwan University |
| 2016 | The Award of Academic Research Thesis in Doctor | National Taiwan University |
| 2015 | The Award of Academic Research Thesis in Master | National Taiwan University |
| 2012 | Young Scientist Oral Presentation Award of the Chinese Society of Animal Science | Chinese Society of Animal Science |
Sin-Jin Li
Position : Assistant Professor
Office : +886-2-3366-9312
E-mail : sinjinli@ntu.edu.tw
Office : +886-2-3366-9312
E-mail : sinjinli@ntu.edu.tw
Research Expertise: Mitochondrial Biology / Lipid Metabolism / Animal Nutrition / Metabolic Syndrome
Obesity is associated with many diseases, including type 2 diabetes (T2DM), hepatic steatosis and cardiovascular disease (CVD). Mitochondrial dynamics, a process of biogenesis, fusion, fission and mitophagy determines mitochondrial morphology, quality and functions. These mitochondrial properties are essential for maintaining healthy mitochondrial networks. Latest studies suggest that these alterations in mitochondrial fission and mitophagy result in the release of damaged extracellular mitochondria (exMito) and associated byproducts that have been shown to induce an inflammatory response in neurodegeneration diseases and sepsis-induced cardiomyopathy models. Furthermore, inhibition of DRP1/Fis1 dependent mitochondrial fission by a rationally designed peptide (P110) may have neuroprotective impact by decreasing the amount of damaged extracellular mitochondria (exMito) released. However, the exact role of this mechanism on metabolic diseases has not been adequately explored.
My current research focus on
1. Regulation of mitochondrial dynamics in the progression of obesity cardiomyopathy
2. Investigating the role of extracellular mitochondria in the progression of obesity induced non-alcoholic fatty liver disease
3. Comparison of the composition of gut microbiota in obese and non-obese Lee-Sung minipigs
Obesity is associated with many diseases, including type 2 diabetes (T2DM), hepatic steatosis and cardiovascular disease (CVD). Mitochondrial dynamics, a process of biogenesis, fusion, fission and mitophagy determines mitochondrial morphology, quality and functions. These mitochondrial properties are essential for maintaining healthy mitochondrial networks. Latest studies suggest that these alterations in mitochondrial fission and mitophagy result in the release of damaged extracellular mitochondria (exMito) and associated byproducts that have been shown to induce an inflammatory response in neurodegeneration diseases and sepsis-induced cardiomyopathy models. Furthermore, inhibition of DRP1/Fis1 dependent mitochondrial fission by a rationally designed peptide (P110) may have neuroprotective impact by decreasing the amount of damaged extracellular mitochondria (exMito) released. However, the exact role of this mechanism on metabolic diseases has not been adequately explored.
My current research focus on
1. Regulation of mitochondrial dynamics in the progression of obesity cardiomyopathy
2. Investigating the role of extracellular mitochondria in the progression of obesity induced non-alcoholic fatty liver disease
3. Comparison of the composition of gut microbiota in obese and non-obese Lee-Sung minipigs
| Ph.D. | Department of Animal Science and Technology, National Taiwan University | 2019 |
| M.S. | Department of Animal Science and Technology, National Taiwan University | 2013 |
| B.S., | Department of Animal Science, National Chiayi University | 2011 |
| Assistant Professor, Bachelor Program of Biotechnology and Food Nutrition, National Taiwan University | 2023-Present |
| Postdoctoral Fellow, Department of Pediatrics, Division of Critical Care, School of Medicine, Stanford University | 2021-2023 |
| Stanford Scientific Teaching Summer Institute, Stanford | 2022 |
| Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica | 2020-2021 |
| Postdoctoral Fellow, Department of Animal Science and Technology, National Taiwan University | 2019-2020 |
| Visiting Scholar, Department of Chemical and Systems Biology, School of Medicine, Stanford University | 2018-2019 |
Years
Article
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Complete publication list
Complete publication list
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2024Wen-Yuan Yang, Pei-En Chang, Sin-Jin Li, Shih-Torng, and Yuan-Yu Lin. Exploring Bile-Acid Changes and Microflora Profiles in Chicken Fatty Liver Disease Model. Animals. 2024; DOI: 10.3390/ani14070992.
Wen-Yuan Yang, Pei-En Chang, Sin-Jin Li, Shih-Torng, and Yuan-Yu Lin. Exploring Bile-Acid Changes and Microflora Profiles in Chicken Fatty Liver Disease Model. Animals. 2024; DOI: 10.3390/ani14070992.
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2023Luis Rios, Suman Pokhrel, Sin-Jin Li, Gwangbeom Heo, Bereketeab Haileselassie, and Daria Mochly-Rosen. Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nature Communications. 2023; DOI: 10.1038/s41467-023-40043-0.
Luis Rios, Suman Pokhrel, Sin-Jin Li, Gwangbeom Heo, Bereketeab Haileselassie, and Daria Mochly-Rosen. Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nature Communications. 2023; DOI: 10.1038/s41467-023-40043-0.
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2023Riddhita Mukherjee, Laura H. Tetri, Sin-Jin Li, Giovanni Fajardo, Nicolai P. Ostberg, Kaleb B. Tsegay, Kanika Gera, Timothy T. Cornell, Daniel Bernstein, Daria Mochly-Rosen, and Bereketeab Haileselassie. Drp1/p53 interaction mediates p53 mitochondrial localization and dysfunction in septic cardiomyopathy. Journal of Molecular and Cellular Cardiology. 2023; DOI: 10.1016/j.yjmcc.2023.01.008.
Riddhita Mukherjee, Laura H. Tetri, Sin-Jin Li, Giovanni Fajardo, Nicolai P. Ostberg, Kaleb B. Tsegay, Kanika Gera, Timothy T. Cornell, Daniel Bernstein, Daria Mochly-Rosen, and Bereketeab Haileselassie. Drp1/p53 interaction mediates p53 mitochondrial localization and dysfunction in septic cardiomyopathy. Journal of Molecular and Cellular Cardiology. 2023; DOI: 10.1016/j.yjmcc.2023.01.008.
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2023Chun-Hsien Chiang, Sin-Jin Li, Yu-Han Lin, Pei-Yu Wang, Pu-Sheng Hsu, Shau-Ping Lin, Ting-Chia Chiang, Ching-Yi Chen. Early-onset caloric restriction alleviates ageing-associated steatohepatitis in male mice via restoring mitochondrial homeostasis. Biogerontology. 2023; DOI: 10.1007/s10522-023-10023-4.
Chun-Hsien Chiang, Sin-Jin Li, Yu-Han Lin, Pei-Yu Wang, Pu-Sheng Hsu, Shau-Ping Lin, Ting-Chia Chiang, Ching-Yi Chen. Early-onset caloric restriction alleviates ageing-associated steatohepatitis in male mice via restoring mitochondrial homeostasis. Biogerontology. 2023; DOI: 10.1007/s10522-023-10023-4.
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2022Chun-Hsien Chiang*, Sin-Jin Li*, Ting-Rui Zhang, Ching-Yi Chen. Long-term dietary restriction ameliorates ageing-related renal fibrosis in male mice by normalizing mitochondrial functions and autophagy. Biogerontology. 2022; doi: 10.1007/s10522-022-09993-8.
Chun-Hsien Chiang*, Sin-Jin Li*, Ting-Rui Zhang, Ching-Yi Chen. Long-term dietary restriction ameliorates ageing-related renal fibrosis in male mice by normalizing mitochondrial functions and autophagy. Biogerontology. 2022; doi: 10.1007/s10522-022-09993-8.
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2022Daniel R. Greenberg, Hriday P. Bhambvani, Satvir S. Basran, Brett P. Salazar, Luis Carl Rios, Sin-Jin Li, Che-Hong Chen, Daria Mochly-Rosen, and Michael L. Eisenberg. ALDH2 expression, alcohol intake, and semen parameters among East Asian men. Journal of Urology. 2022; DOI 10.1097/JU.0000000000002682.
Daniel R. Greenberg, Hriday P. Bhambvani, Satvir S. Basran, Brett P. Salazar, Luis Carl Rios, Sin-Jin Li, Che-Hong Chen, Daria Mochly-Rosen, and Michael L. Eisenberg. ALDH2 expression, alcohol intake, and semen parameters among East Asian men. Journal of Urology. 2022; DOI 10.1097/JU.0000000000002682.
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2022Sin-Jin Li, Yu-Han Lin, Chun-Hsien Chiang, Pei-Yu Wang, and Ching-Yi Chen. Early-onset dietary restriction maintains mitochondrial health, autophagy and ER function in the left ventricle during aging. Journal of Nutritional Biochemistry. 2022; doi: 10.1016/j.jnutbio.2022.108944.
Sin-Jin Li, Yu-Han Lin, Chun-Hsien Chiang, Pei-Yu Wang, and Ching-Yi Chen. Early-onset dietary restriction maintains mitochondrial health, autophagy and ER function in the left ventricle during aging. Journal of Nutritional Biochemistry. 2022; doi: 10.1016/j.jnutbio.2022.108944.
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2021Miao-Ju Chien, Sin-Jin Li, Shiu-Chung Wong, Chun-Hsien Chiang, Yuan-Yu Lin, Harry J Mersmann, and Ching-Yi Chen. Determination of mitochondrial functions and damage in kidney in female LeeSung minipigs with a high-fat diet-induced obesity. Archives of Physiology and Biochemistry. 2021; 10.1080/13813455.2021.1949022.
Miao-Ju Chien, Sin-Jin Li, Shiu-Chung Wong, Chun-Hsien Chiang, Yuan-Yu Lin, Harry J Mersmann, and Ching-Yi Chen. Determination of mitochondrial functions and damage in kidney in female LeeSung minipigs with a high-fat diet-induced obesity. Archives of Physiology and Biochemistry. 2021; 10.1080/13813455.2021.1949022.
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2020Che-Hong Chen, Julio B. Ferreira, Amit U. Joshi, Matthew C. Stevens, Sin-Jin Li, Jade H-M Hsu, Rory Maclean, Nikolas D. Ferreira, Pilar Ramos Cervantes, Diana D. Martinez, Fernando L. Barrientos, Gibran H. R. Quintanares, and Daria Mochly-Rosen. Novel and prevalent non-East Asian ALDH2 variants; implications for global susceptibility to aldehydes’ toxicity. EbioMedicine. 2020; 55: e102753.
Che-Hong Chen, Julio B. Ferreira, Amit U. Joshi, Matthew C. Stevens, Sin-Jin Li, Jade H-M Hsu, Rory Maclean, Nikolas D. Ferreira, Pilar Ramos Cervantes, Diana D. Martinez, Fernando L. Barrientos, Gibran H. R. Quintanares, and Daria Mochly-Rosen. Novel and prevalent non-East Asian ALDH2 variants; implications for global susceptibility to aldehydes’ toxicity. EbioMedicine. 2020; 55: e102753.
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2020Ching-Yi Chen, Sin-Jin Li*, Chia-Yu Wang, Harry J. Mersmann, and Shih-Torng Ding. The impact of DRP1 on myocardial fibrosis in the obese minipig. European Journal of Clinical Investigation. 2020; 50(3):e13204.
Ching-Yi Chen, Sin-Jin Li*, Chia-Yu Wang, Harry J. Mersmann, and Shih-Torng Ding. The impact of DRP1 on myocardial fibrosis in the obese minipig. European Journal of Clinical Investigation. 2020; 50(3):e13204.
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2019Sin-Jin Li, Twin-Way Wu, Miao-Ju Chien, Harry J. Mersmann, and Ching-Yi Chen. Involvement of pericardial adipose tissue in cardiac fibrosis of dietary-induced obese minipigs— Role of mitochondrial function. BBA - Molecular and Cell Biology of Lipids. 2019; 1864(7): 957-965.
Sin-Jin Li, Twin-Way Wu, Miao-Ju Chien, Harry J. Mersmann, and Ching-Yi Chen. Involvement of pericardial adipose tissue in cardiac fibrosis of dietary-induced obese minipigs— Role of mitochondrial function. BBA - Molecular and Cell Biology of Lipids. 2019; 1864(7): 957-965.
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2018Chia-Yu Wang, Sin-Jin Li, Twin-Way Wu, Han-Jen Lin, Jyun-Wei Chen, Harry J. Mersmann, Shih-Torng Ding, and Ching-Yi Chen. The role of pericardial adipose tissue in the heart of obese minipigs. European Journal of Clinical Investigation. 2018; 48(7): e12942.
Chia-Yu Wang, Sin-Jin Li, Twin-Way Wu, Han-Jen Lin, Jyun-Wei Chen, Harry J. Mersmann, Shih-Torng Ding, and Ching-Yi Chen. The role of pericardial adipose tissue in the heart of obese minipigs. European Journal of Clinical Investigation. 2018; 48(7): e12942.
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2018Hsiu-Ching Hsu, Sin-Jin Li, Ching-Yi Chen and Ming-Fong Chen. Eicosapentaenoic acid protects cardiomyoblasts from lipotoxicity in an autophagy-dependent manner. Cell Biology and Toxicology. 2018; 34: 177-189.
Hsiu-Ching Hsu, Sin-Jin Li, Ching-Yi Chen and Ming-Fong Chen. Eicosapentaenoic acid protects cardiomyoblasts from lipotoxicity in an autophagy-dependent manner. Cell Biology and Toxicology. 2018; 34: 177-189.
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2017Sin-Jin Li, Chia-Hsin Liu, Hsien-Pin Chu,Harry J. Mersmann, Shih-Torng Ding, Chun-Han Chu, Chia-Yu Wang, and Ching-Yi Chen. The high-fat diet induces myocardial fibrosis in the metabolically healthy obese minipigs—The role of ER stress and oxidative stress. Clinical Nutrition. 2017; 36: 760-767.
Sin-Jin Li, Chia-Hsin Liu, Hsien-Pin Chu,Harry J. Mersmann, Shih-Torng Ding, Chun-Han Chu, Chia-Yu Wang, and Ching-Yi Chen. The high-fat diet induces myocardial fibrosis in the metabolically healthy obese minipigs—The role of ER stress and oxidative stress. Clinical Nutrition. 2017; 36: 760-767.
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2016Sin-Jin Li, Shih-Torng Ding, Harry J. Mersmann, Chun-Han Chu, Chia-Da Hsu, Ching-Yi Chen. A nutritional nonalcoholic steatohepatitis minipig model. Journal of Nutritional Biochemistry. 2016; 28: 51-60.
Sin-Jin Li, Shih-Torng Ding, Harry J. Mersmann, Chun-Han Chu, Chia-Da Hsu, Ching-Yi Chen. A nutritional nonalcoholic steatohepatitis minipig model. Journal of Nutritional Biochemistry. 2016; 28: 51-60.
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2016Hsiu-Ching Hsu, Chia-Hsin Liu, Yi-Chen Tsai, Sin-Jin Li, Ching-Yi Chen, Chun-Han Chu, Ming-Fong Chen. Time-dependent cellular response in the liver and heart in a dietary-induced obese mouse model- The potential role of ER stress and autophagy. European Journal of Nutrition. 2016; 55: 2031-2043.
Hsiu-Ching Hsu, Chia-Hsin Liu, Yi-Chen Tsai, Sin-Jin Li, Ching-Yi Chen, Chun-Han Chu, Ming-Fong Chen. Time-dependent cellular response in the liver and heart in a dietary-induced obese mouse model- The potential role of ER stress and autophagy. European Journal of Nutrition. 2016; 55: 2031-2043.
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2015Sin-Jin Li, Chia-Hsin Liu, Chei-Wei Chang, Hsien-Pin Chu, Kuen-Jaw Chen, Harry J. Mersmann, Shih-Torng Ding, Chun-Han Chu, and Ching-Yi Chen. Development of a dietary-induced metabolic syndrome model using miniature pigs involvement of AMPK and SIRT1. European Journal of Clinical Investigation. 2015; 45(1): 70-80.
Sin-Jin Li, Chia-Hsin Liu, Chei-Wei Chang, Hsien-Pin Chu, Kuen-Jaw Chen, Harry J. Mersmann, Shih-Torng Ding, Chun-Han Chu, and Ching-Yi Chen. Development of a dietary-induced metabolic syndrome model using miniature pigs involvement of AMPK and SIRT1. European Journal of Clinical Investigation. 2015; 45(1): 70-80.